What is a common sign of developing tolerance to a substance?

The correct answer highlights that as a person develops tolerance to a substance, they often require increasing amounts to achieve the same effect that they initially experienced with smaller doses. Tolerance occurs when the body becomes accustomed to a drug, leading to diminished effects from the usual dose. This phenomenon can occur with various substances, including alcohol, opioids, and many prescription medications.

As tolerance builds, individuals may find themselves taking larger quantities to experience the desired effect, which can lead to increased risk of dependency and potential overdose. Understanding this aspect of substance use is crucial for recognizing patterns of misuse and providing effective interventions.